袁庆芳;石国锋;

• 1:江苏省无锡市人民医院

摘要(Abstract)：

目的观察瑞舒伐他汀钙对脑梗死患者的动脉粥样硬化及脑血流动力学的影响。方法对68例脑梗死患者应用瑞舒伐他汀钙10 mg/d连续口服6个月,观察治疗前后颈内动脉粥样硬化程度、狭窄程度、不稳定斑块及双侧大脑中动脉的血流情况。结果经治疗6个月后,患者不稳定斑块检出率下降,颈内动脉粥样硬化程度、狭窄程度及双侧大脑中动脉的血流情况均较前改善,且治疗前后比较均有显著性差异(P均<0.05)。结论对于脑梗死患者,瑞舒伐他汀钙有稳定及逆转动脉斑块的作用,具有显著抗动脉粥样硬化和改善脑血流动力学的作用,可以在缺血性脑卒中临床二级预防中广泛应用。

关键词(KeyWords)： 瑞舒伐他汀钙;脑梗死;动脉粥样硬化

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 袁庆芳;石国锋;

参考文献(References)：

• [1]Wu ZS,Yao CH,Zhao D,et al.Sino-MONICA Project:a collabo-rative study on trends and determinants in cardiovascular diseases inchina,part I:morbidity and mortality monitoring[J].Circulation,2001,103(5):462-468
• [2]王新德.各类脑血管疾病的诊断要点[J].中华神经科杂志,1996,29(6):379-380
• [3]Handa N,Matsumoto M,Maeda H,et al.Ischemic stroke events andcarotid atherosclerosis.Results of the Osaka Follow-up Study for Ul-trasonographic Assessment of Carotid Atherosclerosis(the OSACAStudy)[J].Stroke,1995,26(10):1781-1786
• [4]Auperin A,Berr C,Bonithon-Kopp C,et al.Ultrasonographic as-sessment of carotid wall characteristics and cognitive funcriions in acommunity sample of 59～71 years old.The EVA Study Group[J].Stroke,1996,27(8):1290-1295
• [5]Amarenco P,Bogousslavsky J,Callahan A 3rd,et al.High-dose a-torvastatin after stroke or transient ischemic attack[J].N Engl JMed,2006,355(6):549-559
• [6]Li JJ,Fang CH.Creactive protein is not only an inflammatory mark-er but also a direct cause of cardiovascular disease[J].Med Hy-photh,2004,62(4):499-506
• [7]Nissen SE,Nicholls SJ,Sipahi L,et al.Effect of very high-intensitystalin therapy on regression of coronary atherosclerosis:the ASTER-OID trial[J].JAMA,2006,295(13):1556-1565
• [8]Tadateru T,Takafumi H,Masakazu Y,et al.Effect of rosuvastatinon coronary atheroma in stable coronary artery disease-mulicentercoronary atherosclerosis study measuring effect of rosuvastatin usingintravascular ultrasound in Japanese subjects(COSMOS)[J].Cir-culation,2009,73(11):2110-2117
• [9]Ballantyne CM,Raichlen JS,Nicholls SJ,et al.Effect of rosuvastatintherapy on coronary artery stenoses assessed by quantitative angiog-raphy:A study to evaluate the effect of rosuvastatin on intravascularultrasound derived coronary atheroma burden[J].Circulation,2008,117(19):2458-2466
• [10]Mora S,Ridker PM.Justification for the use of statins in primaryprevention:an intervention trial evaluating rosuvastatin(JUPITER)-Can C-reactive protein be used to target statin therapy in primaryprevention[J].Am J Cardiol,2006,97(2A):33A-41A
• [11]赵志华,付耀高,刘小艳,等.颈动脉粥样硬化与脑梗死相关性分析[J].中国实用神经疾病杂志,2007,10(5):48-49

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