田冰钰,王丽华

• 1:黑龙江中医药大学
• 2:哈尔滨医科大学附属第二医院

摘要(Abstract)：

<正>重症肌无力(myasthenia gravis, MG)是一种通过乙酰胆碱受体抗体(acetylcholine receptor antibody, AChR-Ab)介导、细胞免疫及补体介入的获得性自身免疫性疾病,表现为受累肌肉无力和易疲劳,劳累后加重且休息后减轻,病情稳定但病程反复。重症肌无力患者也通常伴有甲状腺功能亢进、系统性红斑狼疮等自身免疫性疾病。国外报道称目前重症肌无力的总患病率为每百万人中150～250例,

关键词(KeyWords)： 重症肌无力;发病机制;运动康复

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金资助项目(81571166)

作者(Author): 田冰钰,王丽华

参考文献(References)：

• [1] Gilhus N E,Socrates T,Amelia E,et al.Myasthenia gravis (Primer)[J].Nat Rev Dis Primers,2019,5(1):30.
• [2] Luo J,Lindstrom J.AChR-specific immunosuppressive therapy of myasthenia gravis[J].Biochem Pharmacol,2015,97(4):609-619.
• [3] Lee J I,Jander S.Myasthenia gravis:recent advances in immunopathology and therapy[J].Exp Rev Neurother,2016,17(3):287.
• [4] Wang Y Z,Tian F F,Yan M,et al.Delivery of an miR155 inhibitor by anti-CD20 single-chain antibody into B cells reduces the acetylcholine receptor-specific autoantibodies and ameliorates experimental autoimmune myasthenia gravis[J].Clin Exp Immunol,2014,176(2):207-221.
• [5] 高丽，李壮林.重症肌无力的发病机制及临床治疗研究进展[J].中外医学研究，2019,17(9):173-176.
• [6] Edmundson C,Guidon A C.Eculizumab:A Complementary addition to existing long-term therapies for myasthenia gravis[J].Muscle Nerve,2019,60(1):7-9.
• [7] Hellmann M A,Mosberg-Galili R,Lotan I,et al.Maintenance IVIg therapy in myasthenia gravis does not affect disease activity[J].J Neurolog Sci,2014,338(1-2):39-42.
• [8] Guptill J T,Soni M,Meriggioli M N.Current treatment,emerging translational therapies,and new therapeutic targets for autoimmune myasthenia gravis[J].Neurotherapeutics,2016,13(1):118-131.
• [9] Rowin J,Thiruppathi M,Arhebamen E,et al.Granulocyte macrophage colony-stimulating factor treatment of a patient in myasthenic crisis:effects on regulatory T cells[J].Muscle Nerve,2012,46(3):449-453.
• [10] 黄子天，刘小斌.国医大师邓铁涛强肌健力饮治疗重症肌无力的临床应用及学术传承[J].广州中医药大学学报，2018,35(1):182-185.
• [11] 林海雄，王晓彤，杨伟钦，等.基于数据挖掘的国医大师邓铁涛治疗重症肌无力辨治规律探究[J].辽宁中医杂志，2017,44(12):2526-2529.
• [12] 姜雄，何前松，况时祥.况时祥从“毒”论治重症肌无力的临床经验介绍[J].江苏中医药，2016,48(8):19-21.
• [13] 周韩，邓奕辉，马钟丹妮，等.马培之辨治痿证的学术思想及临床经验[J].中医药学报，2019,47(1):113-116.
• [14] 吴相春，来静.吴以岭诊治重症肌无力的学术思想及经验[J].江苏中医药，2009,41(3):25-26.
• [15] 许凤全.吴以岭教授从奇经和络脉论治重症肌无力经验撷萃[J].四川中医，2006,24(2):4-6.
• [16] Geng Y,Dong J,Zhou Q.Rapid improvement of muscle weakness post-thymectomy indicates good long-term neurological outcome in patients with ocular myasthenia gravis[J].Eur J Neurol,2019,26(11):1421-1423.
• [17] González R,Riquelme U A,Fuentealba S M,et al.Results of extended transsternal thymectomy for Myasthenia gravis.Experience with 58 patients[J].Rev Med Chile,2018,146(4):460-469.
• [18] Schneider-Gold C,Krenzer M,Klinker E,et al.Immunoadsorption versus plasma exchange versus combination for treatment of myasthenic deterioration[J].Ther Adv Neurolog Dis,2016,9(4):297-303.
• [19] Deguchi K,Matsuzono K,Nakano Y,et al.A case of anti-MuSK antibody-positive myasthenia gravis successfully treated with outpatient periodic weekly blood purification therapy[J].Int Med,2018,57(10):1455-1458.
• [20] K?hler W,Bucka C,Klingel R.A randomized and controlled study comparing immunoadsorption and plasma exchange in myasthenic crisis[J].J Clin Apheresis,2011,26(6):347-355.
• [21] 刘畅，赫群.针灸治疗重症肌无力型上胞下垂55例[J].实用中医药杂志，2017,33(11):1306-1307.
• [22] 徐兴华，代东良，方晓丽.“温通针法”针刺风池穴为主治疗眼肌型重症肌无力30例[J].中国针灸，2016,36(9):939.
• [23]杨俊红，杨丽丽，陈英哲，等．中药联合电针治疗重症肌无力62例的临床疗效观察[J]．中医临床研究，2016,8(26):67-68.
• [24]卢传辉．胸腺手术切除配合隔姜灸治疗重症肌无力临床观察[J]．实用中医药杂志，2019,35(10):1219-1220.
• [25]费敏，乐文蔚，冯静，等．眶周穴位按摩结合甲强龙穴位注射在提高眼肌型重症肌无力患者眼肌疗效的应用研究[J]．护士进修杂志，2018,33(16):1446-1448.
• [26]徐化金，高学军．温针合梅花针治疗重症肌无力眼肌型36例[J]．河北中医，2001,23(1):47.
• [27]康丽萍，杨云英，崔晓演，等．中医外治法干预重症肌无力患者的临床结局评价研究[J]．广州中医药大学学报，2020,37(5):833-837.
• [28]O’connor L,Westerberg E,Punga A R. Myasthenia Gravis and Physical Exercise:A Novel Paradigm[J]. Front Neurol,2020,11:675.
• [29]Westerberg E,Molin C J,Lindblad I,et al. Physical exercise in Myasthenia Gravis is safe and improves neuromuscular parameters and physical performance-based measures:A pilot study:Physical exercise in MG[J]. Muscle Nerve,2016,56(2):207-214.

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